A regenerative pairing: GF 15% Solution and Lacto-PDRN* 4% + B9 Eye Cream

Skin renewal is a complex process influenced by multiple factors.

Supporting visible renewal requires ingredients that help maintain skin health and improve the appearance of concerns associated with aging, such as fine lines, uneven texture, and loss of firmness both immediately and over time.

The Ordinary’s pairing of GF 15% Solution and Lacto-PDRN* 4% + B9 Eye Cream, brings together two complementary technologies designed to promote skin renewal and visible long-term benefits.

Learn how they complement one another, and how to use them together for visibly smoother, firmer, more resilient skin.

September 30, 2026

What Is GF 15% Solution?

GF 15% Solution is a lightweight growth factor serum formulated to regenerate the look of aging skin across the face and neck. With a 15% concentration of three next-generation growth factors, this water-based serum helps address advanced signs of aging like fine lines, wrinkles and uneven texture and tone.

Growth factors are proteins that play an essential role in skin health and renewal. By mimicking these natural proteins, the growth factors in our GF 15% Solution support skin renewal and promote elasticity and firmness:

  • EGF: Promotes elasticity and firmness

  • IGF-1: Supports skin density and collagen production.

  • TGFβ-2: Helps reduce visible lines and wrinkles while promoting firmness and elasticity.

GF 15% Solution can be used daily in both your AM and PM regimen.


What Is Lacto-PDRN

Lacto-PDRNTM is a bio-engineered regenerative ingredient that supports the skin’s natural renewal processes to help improve the look of firmness and elasticity. Traditionally derived from salmon, our vegan lacto-PDRNTM is derived through the fermentation of lactobacillus rhamnosus, a probiotic bacterium.

Fermentation breaks down the bacterium into short sodium DNA fragments, which form Lacto-PDRNTM. These fragments signal the skin’s renewal processes to help target signs of aging.

Despite the name, Lacto-PDRNTM has no connection to milk or dairy. The prefix “lacto” refers to the Lactobacillus strain used in the fermentation process.

Lacto-PDRN™ was chosen for our newest eye cream based on its strong, eye-area-specific data, resulting in a gentle yet effective formulation designed to target key concerns around the eyes.


How These Two Formulations Work Together

When layered, GF 15% Solution and Lacto-PDRN* 4% + B9 Eye Cream supports skin renewal. While a growth factor serum like GF 15% Solution focuses on regenerating the look of aging skin on the face and neck, and strengthening the skin barrier, lacto-PDRNTM promotes renewal and targets concerns such as loss of firmness, appearance of fine lines wrinkles, and smoothness for the delicate eye area.

Together, this pairing supports multiple aspects of skin regeneration:

  • Reduce the look of lines and wrinkles

  • Firm and lift skin

  • Smooth uneven texture

  • Enhance skin radiance

  • Support stronger, more resilient skin

Layering these advanced skincare technologies provides a comprehensive approach to skin renewal, with visible results both immediately and over time


How to Use the Pairing in a Regimen

Incorporate the formulations within your existing regimen as follows:

  1. Prep:
    Remove makeup and impurities with a gentle cleanser like Squalane Cleanser.

    
    
  2. Treat:
    Apply GF 15% Solution to clean, dry skin in your AM and PM routines. Follow with any remaining serums, then apply Lacto-PDRN* 4% + B9 Eye Cream around the eye area.

    
    
  3. Seal:
    Finish with a rich, barrier-supportive moisturizer such as Natural Moisturizing Factors + PhytoCeramides. In the AM, follow with SPF to help protect skin from UV exposure.


What to Expect with Consistent Use

While Lacto-PDRN™ 4% + B9 Eye Cream delivers instant firming, the pairing is designed to support longer-term results. With consistent use, you can expect gradual, visible improvements in skin texture, lifting, elasticity, firmness, and signs of aging over time.

Testing of GF 15% Solution shows:

  • Immediate improvement of the look of rough skin and enhanced skin radiance.

  • Visible wrinkle repair in 1 week*.

  • Visible repair of skin damage in 2 weeks**.

  • Firms the face and neck in 4 weeks*** and jawline looks more lifted***.

  • Stronger, more resilient with one use.

*Clinical testing on 42 people, using the product 2x/day for 1 week.
**Clinical testing on 42 people, using the product 2x/day for 2 weeks.
***Clinical testing using the product 2x/day for 4 weeks.

Testing of Lacto-PDRN* 4% + B9 Eye Cream shows:

  • Visible eyelid lifting from first use** with continued improvement.

  • Immediate tightening of under-eye bags.

  • Visible firming, tightening, and brightening of the skin around the eye area.

  • Improved skin firmness and elasticity.

  • Smoothed texture and crepey eyelids by -17% after 8 weeks*.

  • Minimized appearance of fine liner under the eye by -18% after 8 weeks*.

*Clinical testing on 32 panelists using the product 2x / day for 8 weeks.

**Clinical testing on 32 panelists after using the product once

Tips for Supporting Skin Renewal

Skin renewal is a gradual process that benefits from consistent skincare habits and ingredients that support visible improvements over time. Some tips to incorporate into your routine include:

1. Be consistent and patient

Benefits are cumulative. Results develop gradually, over time with consistent use. Don’t give up if you don’t see immediate results.

2. Avoid overloading the skin with strong exfoliants

Strong exfoliants can temporarily disrupt the skin barrier and slow your efforts. Ensuring your routine includes hydrating and barrier supporting ingredients is key for safety and efficacy.

3. Prioritize sleep

Adequate sleep is an important factor in skin health. Do your best to get enough sleep for your age, lifestyle, and individual needs.

4. Don’t skip your sunscreen

Daily application of a broad-spectrum SPF is one of the best ways to protect your skin and prevent damage from UV exposure.


Skin Renewal FAQs

Growth factors are signalling molecules involved in communication between skin cells. In skincare, growth factor technologies are used to support visible improvements in concerns associated with aging, including the appearance of fine lines, firmness, and elasticity.

Lacto-PDRN supports visible skin renewal by helping improve the appearance of firmness, elasticity, and texture.

Yes, these formulations can be used together. When paired with each other, they provide a more comprehensive approach to skin renewal that targets both face and eye skin.

The pairing of GF 15% Solution and Lacto-PDRN* 4% + B9 Eye Cream is best suited for anyone looking to address visible signs of aging for both face and eye skin, including fine lines, loss of firmness, and uneven texture.

Visible results can vary depending on the concern being addressed and the individual’s skin. Some benefits may be seen immediately, while other visible improvements develop gradually with consistent use.

Clinical testing showed immediate improvements following application, with continued visible improvements over time. Additional testing demonstrated visible improvements in concerns such as skin texture, lifting, firmness, and signs of aging after 2 weeks of consistent use, with further improvements observed with continued use.


2 Formulations. One Routine.

GF 15% Solution and Lacto-PDRN* 4% + B9 Eye Cream combine growth factor technology with advanced regenerative support to address visible skin renewal from multiple angles. Using GF 15% Solution and Lacto-PDRN* 4% + B9 Eye cream together, helps support visible skin renewal and improve the appearance of firmness, elasticity, and resilience over time.