NIOD SDSM2 vs. SDEM3: Which Antioxidant Mist Is For You?

Defence is relevant to all of us in our daily life, as our skin is constantly exposed to pollution, smoke, vehicle emissions and harsh weather that can negatively impact the structural quality of our skin. Over time, this damage builds, and can lead to signs of premature skin ageing such as fine lines and wrinkles, dullness, uneven skin tone, and an increase in dark spots.

This article explores the evolution of our antioxidant mists technology, comparing our Superoxide Dismutase Saccharide Mist (SDSM2) with our latest innovation, Superoxide Dismutase 3 Enzyme Mist (SDEM3). Understanding their unique properties will help you choose the best antioxidant defense for your skin’s needs.

Antioxidants support the skin’s defence against environmental stressors and prevent visible skin damage before it occurs, ultimately helping to prevent early signs of ageing.

Both of our formulations include Superoxide Dismutase (SOD) antioxidants, which are known to be one of the most potent antioxidants naturally found in the skin. SOD are one of the most effective defenders against environmental stressors and offer significant support to help mitigate damage.

Superoxide Dismutase Saccharide Mist (SDSM2) is our second-generation treatment mist designed to offer essential protection against environmental stressors and water loss, with the goal of maintaining visible quality of skin.

SDSM2 primarily addresses

• Dryness
• Supports the visible maintenance of skin quality
• General antioxidant support

Key Features of SDSM2

• Superoxide Dismutase (SOD): The specific type of SOD used in SDSM2 is called Cu/Zn SOD - made to mimic the skin's natural SOD antioxidants so that it’s skin-compatible. Topically increasing SOD helps encourage our skin’s ability to protect against environmental stressors, resulting in healthier-looking skin.


• Pseudoalteromonas Exopolysaccharides: A marine-derived ingredient which works to increase skin hydration with benefits comparable to Hyaluronic Acid. This results in a reduction in the appearance of fine lines and wrinkles, as well as improved skin hydration.

Superoxide Dismutase 3 Enzyme Mist (SDEM3) is an antioxidant powerhouse that harnesses Superoxide Dismutase 3 (SOD3). After 3 years in the lab, we feature this ingredient newly isolated in our skincare for the first time.

What Makes SDEM3 Different? The Power of SOD3

SOD1 and SOD2 molecules and how they work within cells have been explored in skincare, but SOD3 hasn't been isolated in our skincare line–until now.

Maintaining the skin’s natural collagen as we age helps combat visible fine lines, wrinkles and premature ageing. Whereas SOD1 and SOD2 remain unchanged, the levels of SOD3 enzyme supporting these skin functions significantly decrease in aged skin, So NIOD created a product that delivers it to the skin.

The Unique Advantage of SOD3

Naturally occurring SOD3's unique advantage lies in its location and function—it operates outside skin cells. In this position, SOD3 acts as the first line of defence, preserving skin’s natural collagen levels.

Additionally, our new SDEM3 formulation utilises a topical SOD3, which helps preserve collagen levels and helps prevent visible premature signs of skin ageing.

Beyond SOD3, the new Superoxide Dismutase 3 Enzyme Mist (SDEM3) formulation incorporates a blend of advanced technologies for comprehensive skin support:

• Superoxide Dismutase 3 (SOD3): Helps mitigate the impacts of environmental stressors on skin that contribute to the loss of collagen, structural integrity and early onset of visible signs of ageing.
• Oxidized Glutathione: Functions as an antioxidant precursor that serves to brighten and balance uneven skin tone.
• Algin and Biosaccharide Gum - 4: Forms a tightening layer on the skin, that smooths fine lines and enhances firmness. Algin boosts hydration by mimicking the skin's Natural Moisturizing Factors (NMF), for retained moisture.
• Acetyl Zingerone: Protects against visible skin damage caused by free radicals for improved appearance of fine line and wrinkles.
• Nicotiana Benthamiana Hexapeptide-40 sh-Polypeptide-2: Mimics a protein naturally found in skin that targets dullness for brighter looking skin

SDEM3 Offers a Broader Range of Benefits, Including:

• Helps prevent collagen depletion
• Visibly Repairs Wrinkles
• Helps mitigate environmental skin damage
• Delivers instant hydration
• Restores radiance and tone

NIOD offers a thoughtful collection of products designed for robust antioxidant protection. Choosing between SDSM2 and SDEM3 depends on your primary skin concerns and desired level of defence:

NIOD offers a thoughtful collection of products designed for antioxidant protection. Whichever you integrate, you know you’re choosing wisely.